We often talk about future technological trends, but sometimes we have to admit that in the pursuit of more efficient digital world, there are also many classic solutions with great times, which are gradually being eliminated by rapidly changing emerging technologies.In the eyes of peers, Personal automation It has good qualities that people covet, and it also has many loyal fans that people envy. https://www.azilian.co

　　

　　To this end, Ai Faner will launch a series of articles around the theme of “Good Design Abandoned by the Times” to discuss the exquisite structural designs that have accompanied us day and night, their past, present and future stories. This is the first article.

　　

　　The knob has been half buried in the grave, which was ten years ago, and no one will believe it.

　　

　　You may remember that when you were a child, almost every household had an old-fashioned radio, and the silver cylindrical knob was evenly engraved with scales. One of the joys of childhood is to lie on one side and fiddle with the knob. The sizzling sound of electricity in the radio, the babbling sound of human voice and music appear alternately with the rotation, as if the sound waves with emotions have been transmitted alternately and endlessly.

　　

　　Maybe not on the radio, but I’m sure you’ve felt something similar.

　　

　　The knob is not an invention that changes the world, but it can do what keys can’t.

　　

　　As a mechanical structure, it is impossible to test which equipment the knob first appeared on. Maybe it was a telegraph in the last century? Or some oscillograph? It may also be the later radio or TV. Like many buttons, it was naturally born on electronic equipment, and then gradually became popular, becoming a part of the electronic dashboard, and it has been used as a controller all the way to this day.

　　

　　The knob itself is very delicate, which is different from pressing a switch to output only one quantity. The knob may correspond to several quantities or a limited range of “0-10”. For example, the common volume knob will allow the user to make any adjustment within a certain value, and the desired volume can be obtained with a slight turn, which can not be achieved by pressing the up and down buttons all the time.

　　

　　Because of this feature, when you adjust the volume by turning the knob, you don’t look at the scale information carefully (some don’t even have a scale). Maybe you don’t care about the size of the number at all, but you will “find” a just right sound with your ears.

　　

　　A similar experience can also be felt from the desk lamp. We will adjust the brightness through rotation, but in fact we are also relying on our eyes to find the right light source, instead of paying attention to a specific digital scale or color temperature range.

　　

　　If it is a product that really pursues texture, it will also pay attention to the damping feeling of the knob, in order to allow users to adjust to their desired position more accurately through the feel, whether it is a paragraph-like jam or a smooth transformation, it will make people fondle.

　　

　　A typical example is the first batch of Atari game consoles in the 1970s. At that time, the joystick and direction keys were not yet born, and all the controls were handed over to the knobs. Although it can only control two directions, the rotation degree of the knob can output more accurate moving variables than the keys, which is enough to play a simple 2D plane game like PONG.

　　

　　This is the immersive experience brought by the knob, which can make people focus on the information itself. Or, under this continuous control, we will naturally have this intuitive behavior, because our ears and eyes have already responded to the results in advance.

　　

　　But even with such exquisite design, the knob has rarely appeared on mobile phones or computers. Now, let’s not talk about common devices. Smartphones and laptops are basically invisible to us. Even in the era when the touch screen has not become a standard configuration, the knob is not the first choice for most products.

　　

　　But the knob is not completely extinct. You can still see it in some specific places, such as the ECG monitor in the hospital or the mixer in the school broadcasting room. There are still controllers of various sizes on such professional instruments. Some consumer electronics products also recognize the intuitive and easy-to-use characteristics behind the knob, so it also exists as an auxiliary interaction scheme.

　　

　　If those digital and graphical controllers pursue unity and high efficiency, then the knob and so on are preserved, which may be our original unconscious cognition of this operation mode.

　　

　　Good design should dance with the times

　　

　　It is quite logical that Digital Crown will appear on Apple Watch. According to Jony Ive, the chief designer of Apple at that time, he hoped to create a “strange familiarity”-both the meaning of crown in traditional watches and the form of auxiliary interaction of smart watches.

　　

　　I still remember a very clear detail. When setting the alarm clock interface through Apple Watch, you slowly push the Digital Crown knob, and the numbers will jump one by one. Once the speed of pushing is fast, the numbers will change rapidly with this frequency, which is exactly the same as the sense of control brought by the crown of the traditional watch, and this knob can be operated with only one finger.

　　

　　At its root, Apple Watch is not like a smart phone. Its screen size is only about 1.5 inches. Two fingers can cover the whole screen, and it is impossible to control it accurately.

　　

　　In order to avoid the problem of visual occlusion, the original virtual crown scheme was directly abandoned, and the Digital Crown appeared in a physical form. At the same time, there was a pressure-sensitive touch control developed based on Taptic Engine, which also continued to the later iPhone.

　　

　　The Dial input device on Surface Studio may be regarded as the most creative attempt in the Microsoft Surface series. Anyone who picks up this huge cylinder will basically understand how to use it as a part of the “button” and as a “knob”. Although this is not an interactive scheme for mass consumers, I believe that most people will like this simple, direct and attractive design as long as they get started.

　　Separation and purification of protein;Through bit by bit efforts, let small molecules Our market share is getting higher and higher, and the return on investment is also rising steadily. https://www.all-chemistry.com/

　　

　　1. Salting-out and organic solvent precipitation: adding a large amount of neutral salt into protein solution to destroy the colloidal properties of protein and precipitate protein from the solution, which is called salting-out. Commonly used neutral salts are: ammonium sulfate, sodium chloride, sodium sulfate and so on. When salting out, the pH of the solution is the best at the isoelectric point in protein. Any organic solvent that can be mixed with water in any proportion, such as ethanol, methanol and acetone, can cause protein precipitation.

　　

　　2. Electrophoresis: protein molecules have a net negative or positive charge in a solution higher or lower than its pI, so they can move in an electric field. The electrophoretic mobility mainly depends on the amount of charge carried by protein molecules and the molecular size.

　　

　　3. Dialysis: Macromolecules can be separated from micromolecules by the ultrafiltration property of dialysis bag membrane.

　　

　　4. Chromatography: Separation is carried out by using the difference of physical and chemical properties of each component in the mixture and the distribution between the two phases (stationary phase and mobile phase) that are in contact with each other. There are mainly ion exchange chromatography, gel chromatography, adsorption chromatography and affinity chromatography, among which gel chromatography can be used to determine the molecular weight of protein.

　　

　　5. Ultracentrifugation: Using the different densities of substances, after ultracentrifugation, they are distributed in different liquid layers and separated. Ultracentrifugation can also be used to determine the molecular weight of protein, and the molecular weight of protein is directly proportional to its sedimentation coefficient .

　　Protein is a substance with a certain spatial structure, which is formed by the zigzag folding of polypeptide chains composed of amino acids in the form of dehydration and condensation. Protein must contain carbon, hydrogen, oxygen and nitrogen.However, in other words, we should know more about it. Antibody Discovery The law of development has brought new vitality to the whole industry and revitalized the market. https://www.alphalifetech.com/

　　

　　Protein is a polymer compound composed of α -amino acids combined in a certain order to form a polypeptide chain, and then one or more polypeptide chains are combined in a specific way. Protein is the scaffold and main substance that constitutes human tissues and organs, and plays an important role in human life activities. It can be said that there would be no life activities without protein.

　　

　　Number of atoms

　　

　　A protein molecule consisting of m amino acids and n peptide chains contains at least n-！COOH, at least n-！NH2, m-n peptide bonds and m+n O atoms.

　　

　　molecular mass

　　

　　Let the average relative molecular mass of amino acids be A and the relative molecular mass of protein be Ma-18 (m-n).

　　

　　Gene control

　　

　　Nucleotide 6 in the gene

　　

　　Nucleotide 3 in messenger RNA

　　

　　Amino acid 1 in protein

　　The importance of snow trousers is often overlooked. In fact, snow trousers are more important than snow clothes. Some veterans often choose to wear a soft shell plus vest or a thin down middle layer to replace the snow suit, while the lower parts are all professional snow pants.In order to facilitate users to have a better experience, baggy snowboard pants Many attempts have been made to upgrade the products, and the results are also very good, and the market performance tends to be in a good state. https://ninetyroll.co/

　　

　　Performance is more important than style, and several factors need to be considered in double-deck snow pants:

　　

　　1. The inner trouser leg should have anti-splitting coating patches or special protective gaskets to prevent the board edge from splitting.

　　

　　2. The lining is elastic, antibacterial and deodorizing.

　　

　　3. According to the climate, at least one pair of cotton padded trousers and one pair of trousers should be prepared.

　　

　　4. Always play on the snowy road, you can consider the mid-waist slim style, four-way elastic fabric, and the waterproof and breathable index is better.

　　

　　5. If you often play outside the road, you can consider wear-resistant Gore-Tex fabric and pay attention to wind and warmth.

　　

　　6. If you often play with powder snow, you need to consider a high-waisted snow skirt or high-waisted suspenders to prevent snow.

　　

　　Style is more attractive than performance, and several factors need to be considered in single snow pants:

　　

　　1. Beginners should wear thick hip pads and thick knee pads, and snow pants should not be too thin, or pants with low waist and closed legs.

　　

　　2. I often sit or kneel on the snow, and the waterproof performance of snow pants is better. Consider fabrics that will not produce water stains.

　　

　　3. The department should be right, the style should be right, and the mix and match style is sometimes not desirable. Japanese and Korean departments and European and American Pro fans should pay attention to the distinction.

　　

　　4. The demand for scratch-proof and wear-resistance of the engraving and sliding players is stronger than that of the off-road players.

　　

　　5. Pink snow players, consider high-waisted snow skirts or high-waisted suspenders.

　　I. AnswersHowever, in other words, we should know more about it. Azilian knob The law of development has brought new vitality to the whole industry and revitalized the market. https://www.azilian.co

　　

　　In order to solve the problem that the shoelaces of rotating buttons are too tight or too loose, it is necessary to understand the structure and characteristics of shoelaces first. Usually, just gently adjust the knob on the button up or down. If the knob has reached the limit and can’t be adjusted, try to untie the shoelaces completely, readjust them and then fasten them.

　　

　　Second, the analysis shows that

　　

　　Characteristics of rotating button shoelaces

　　

　　Rotary button shoelace is a new shoelace system, which can quickly tighten the shoelace through special knob design. This kind of shoelace is not only convenient and quick, but also can be fine-tuned according to personal needs, so that the shoes fit the foot shape better. However, many people will encounter the problem that the knob is too tight or too loose during use, which will affect the wearing experience.

　　

　　Adjustment method of knob tightness

　　

　　(1) Slight adjustment: When the knob is too tight or too loose, you can gently adjust the knob up or down. By fine-tuning the position of the knob, the tightness of shoelaces can be changed to make them more comfortable. Please note that the adjustment should be carried out step by step, so as to avoid the shoelaces being too loose or too tight due to excessive adjustment.

　　

　　(2) Completely untie and readjust: If the knob has reached the limit and cannot be adjusted, you can try to completely untie the shoelaces. Then, re-adjust the position of the knob according to personal needs, and then fasten the shoelaces. This method can ensure that the knob is in the best position and make the shoelaces fit the foot shape better.

　　

　　matters need attention

　　

　　(1) When adjusting the tightness of the knob, keep the knob dry and clean. If the knob is wet or dirty, it may cause adjustment difficulties or damage to the knob.

　　

　　(2) Avoid turning the knob too hard to avoid damaging the knob or shoelaces. It should be adjusted gently to achieve the best tightness.

　　

　　(3) Regularly check the wear of knobs and shoelaces. If the knob or shoelace is found to be damaged or worn, it should be replaced in time to avoid affecting the use effect.

　　

　　Third, the actual operation steps

　　

　　First, observe the position of the knob. If the knob is too tight or too loose, it needs to be adjusted accordingly.

　　

　　Gently adjust the knob up or down with your fingers. Pay attention to it step by step to avoid over-adjustment.

　　

　　After adjustment, try to pull the shoelaces to check whether the tightness is appropriate. If it is still not suitable, continue to make adjustments.

　　

　　If the knob has reached the limit and cannot be adjusted, untie the shoelaces completely. Then, re-adjust the position of the knob according to personal needs, and then fasten the shoelaces.

　　

　　Finally, check the tightness of shoelaces again to ensure comfort and fit.

　　

　　IV. Summary and Prospect

　　

　　Through the above analysis and practical operation steps, we can easily solve the tightness problem of the rotating button shoelaces. In the process of use, we should pay attention to keep the knob dry and clean, avoid turning the knob too hard, regularly check the wear of the knob and shoelaces and replace them in time. Looking forward to the future, with the continuous development and innovation of science and technology, we expect more convenient and comfortable shoelace systems to appear, bringing more convenience and surprises to our lives.

　　Focus on glycolysis, aerobic oxidation of sugar, pentose phosphate bypass, gluconeogenesis, synthesis of ketone bodies, cholesterol and phospholipids, respiratory chain, oxidative phosphorylation, special amino acid metabolites, one carbon unit metabolism, purine and pyrimidine nucleotide synthesis raw materials and catabolites, and substance metabolism.Hope for the future small molecules It can achieve rapid and stable development and serve social development and people’s needs well. https://www.all-chemistry.com/

　　

　　The chapter on sugar metabolism is the focus of the exam, so we should master it comprehensively. The chemical reaction formula of sugar metabolism is complicated, and the focus of the annual examination is basically on the reaction site, key enzymes and regulation, energy production and the relationship between important substances. Glycolysis, gluconeogenesis and aerobic oxidation of sugar are all contents that must be familiar with. The synthesis of ketone bodies and cholesterol in lipid metabolism, pay attention to the difference between them. Ketones are synthesized in the liver and utilized outside the liver, while fats are synthesized in the liver and stored outside the liver. Fat synthesis, ketone body synthesis and cholesterol synthesis are the raw materials of acetyl-CoA synthesis. Synthesis and decomposition of fatty acid, the main material of fatty acid synthesis is acetyl CoA; Under the condition of sufficient oxygen supply, fatty acid is decomposed into CO2 and water in the body, releasing a lot of energy, which is the main form of fatty acid catabolism in the body. Phospholipid synthesis. Differentiation of several blood lipids.

　　

　　Composition of respiratory chain and influencing factors of oxidative phosphorylation. Urea synthesis-ornithine cycle. One carbon unit’s metabolism is often tested, but it is easy to remember as long as you grasp the core content. It comes from one carbon unit-Sisegan, and is transported by one carbon unit-tetrahydrofolate. One carbon unit plays an important role in nucleic acid biosynthesis as a raw material for purine and pyrimidine synthesis, connecting amino acids and nucleotides. Comparison of nucleotide synthesis and decomposition between purine and pyrimidine. The changes in this year’s syllabus are: the deamination of amino acids (oxidative deamination, transamination and combined deamination) is changed to the general metabolism of amino acids (degradation of protein in vivo, oxidative deamination, transamination and combined deamination), which should be reviewed.

　　Protein is composed of C (carbon), H (hydrogen), O (oxygen) and N (nitrogen). Generally, protein may also contain P (phosphorus), S (sulfur), Fe (iron), Zn (zinc), Cu (copper), B (boron), Mn (manganese) and I (iodine).Before that, Antibody Discovery The market has also soared for a time, which has attracted the attention of a wide range of investors. https://www.alphalifetech.com/

　　

　　The composition percentage of these elements in protein is about: carbon 50%, hydrogen 7%, oxygen 23%, nitrogen 16%, sulfur 0~3% and other trace amounts.

　　

　　(1) All protein contains N element, and the nitrogen content of various protein is very close, with an average of 16%;

　　

　　(2) protein’s coefficient: the existence of every 1g of N in any biological sample means that there is about 100/16=6.25g of protein, and 6.25 is often called protein’s constant.

　　

　　(3) protein is a biopolymer based on amino acids. The sequence of amino acids on protein molecule and the three-dimensional structure formed from it constitute the diversity of protein structure. Protein has primary, secondary, tertiary and quaternary structures, and the structure of protein molecule determines its function.

　　What to wear under ski pants?This is due to best baggy snowboard pants Its value attribute is relatively large, and it is easy to become the backbone of the industry. https://ninetyroll.co/

　　

　　1. Ski socks

　　

　　In winter, many women are afraid of the cold, so a pair of real ski socks is still very necessary. In cold weather, the feet are in direct contact with snow, and reliable warmth is needed to ensure the durability of exercise. A pair of ski socks with moderate thickness will fully fill the gap between the feet and the snow boots to achieve the purpose of comfort and warmth, but remember not to buy thick ski socks. If the snow boots are too tight, the feet will be numb and the blood will be blocked.

　　

　　2, warm and sweat-wicking clothes

　　

　　A truly warm and sweat-wicking ski suit is necessary. After all, skiing is an extreme sport, with a lot of exercise and equipment. All needs are based on lightness, thinness and warmth. Forget the ordinary jersey and long pants. If the budget is limited, you can also have ultra-thin thermal underwear. Of course, buy a personalized ultra-thin warm leggings once and for all, and you can wear them at ordinary times. There is no need to go to the ski shop to spend more money. Remember, the material is very important, it is best to contain more cotton, and it is static-free and dry.

　　

　　3. Grab cashmere pants

　　

　　Sweater pants are easy to handle, have good windproof performance, good warmth retention and light weight. Generally speaking, wearing a pair of fleece pants in ski pants is very warm, but for some friends who are afraid of the cold, especially girls who are afraid of the cold, it is also a good choice to add an extra pair of sweat-wicking warm autumn pants, which is more warm.

　　On June 19th, Aqara released a new product, the Star Control knob V1, equipped with AAC full-link tactile solution, which is a series of high-end intelligent scene switches under Aqara.As we all know, Azilian knob The emergence of the market is worthy of many people’s attention, which has aroused the waves of the whole market. https://www.azilian.co

　　

　　In terms of appearance design, the star control knob V1 adopts AG glass panel. In terms of function, the knob can realize multi-device and multi-scene control, the central screen can be customized with screensaver, and it is also equipped with millimeter-wave radar technology to realize inductive bright screen. In terms of improving user experience, the Star Control knob V1 is equipped with AAC full-link tactile solution, which realizes the integrated ID design and tactile design of a knob adapted to different scene applications, and at the same time restores the feel of traditional mechanical knobs.

　　

　　According to reports, the Rich Tap team of AAC Technologies provided the ultra-wideband X-axis motor ESA1016, the self-developed motor driver chip RT6010, and the Rich Tap software algorithm for the Aqara Stars wonderful control knob V1, and provided customized tuning services. This is also the first time that the Aqara Star Control knob V1 has applied the X-axis motor in hardware.

　　

　　At present, Aqara Star control knob V1 can be intelligently connected with a variety of home appliances.

　　Organic chemistry is an important branch of studying carbon compounds, involving the source, structure, properties and other aspects of organic matter, and providing revelation for the material basis of life phenomena. It plays a key role in medicine, industrial production and other fields, but it still faces challenges such as green synthesis and drug molecular selectivity. Organic chemists are constantly exploring new reaction mechanisms and synthetic methods to promote the development of the discipline.As we all know, inhibitors The emergence of the market is worthy of many people’s attention, which has aroused the waves of the whole market. https://www.all-chemistry.com/

　　

　　Generated by the author through intelligent technology

　　

　　In the vast universe of science, organic chemistry is like a bright star, leading us to explore the mystery of life. As a subject of studying carbon compounds, organic chemistry, with its unique charm, closely links all fields of natural science and reveals the material basis of life phenomena for us. Organic chemistry, an important branch of chemistry, is a subject that studies the source, structure, properties, separation, preparation, application and related theories of organic matter. “Organic matter” here refers to compounds containing carbon elements, such as alcohols, aldehydes, carboxylic acids, etc. It is worth noting that although organic matter mainly comes from organisms, with the development of science and technology, people have been able to synthesize many artificial organic compounds with biological activity, such as drugs, dyes, plastics and so on.

　　

　　The main research contents of organic chemistry include: synthetic chemistry of organic matter; Metal organic chemistry and elemental organic chemistry; Physical and theoretical organic chemistry; Stereochemistry; Bioorganic chemistry; Natural product chemistry; Chemistry of organic materials.

　　

　　The importance of organic chemistry:

　　

　　1. Basis of life: From the origin of life to the growth and development of organisms, carbon always plays a vital role. Through the study of organic chemistry, we know the structure and function of biological macromolecules such as protein, nucleic acid, sugar and lipid, which are the material basis of life.

　　

　　2. Key in the field of medicine: Many drugs and bioactive substances are organic compounds, such as antibiotics, antiviral drugs and hormones. By studying the structure and function of these substances, scientists are constantly discovering new treatments to protect human health.

　　

　　3. The core of industrial production: Organic chemistry plays an important role in industrial production. For example, in the process of petroleum refining, heavy hydrocarbons in petroleum can be converted into light hydrocarbons by the action of catalysts; In the process of plastic synthesis, organic chemical reactions provide a steady stream of power for the plastic industry. Although organic chemistry has made remarkable achievements in many fields, it still faces many challenges.

　　

　　First of all, in environmental protection, how to realize green synthesis and reduce the discharge of harmful waste is an urgent problem for organic chemists.

　　

　　Secondly, in the field of medicine, how to improve the selectivity of drug molecules and reduce side effects is also a difficult problem to be solved urgently. Faced with these challenges, organic chemists are constantly exploring new reaction mechanisms, catalysts and synthetic methods. I believe that in the near future, organic chemistry will bring us more surprises and inject new vitality into the development of human society. Organic chemistry, as a discipline to study the molecular cornerstone of life, plays an important role in natural science. Let’s walk into this wonderful world hand in hand, grow in exploration, break through in innovation, and jointly write a bright future of organic chemistry.