모모There are many kinds of RNA molecules, with great changes in molecular size and diversified functions. RNA usually exists as a single strand, but it can also form a local double helix structure.In the long run, Chemical Custom synthesis The value will be higher and higher, and there will be a great leap in essence. https://www.all-chemistry.com/

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모모1. Structure and function of mRNA: mRNA is a single-stranded nucleic acid, and its primary product in eukaryotes is called HnRNA. Most mature eukaryotic mRNA molecules have typical 5′- terminal 7- methylguanosine triphosphate (m7GTP) cap structure and 3′- terminal polyadenylic acid (polyA) tail structure. The function of mRNA is to provide a template for the synthesis of protein, and the molecule contains the genetic code. Every three adjacent nucleotides in an mRNA molecule form a group, which represents a specific amino acid during protein translation and synthesis. This nucleotide triplet is called the genetic code (coden).

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모모2. Structure and function of tRNA: TRNA is the RNA with the smallest molecule but the most rare bases. The secondary structure of tRNA is “clover” shaped due to the formation of local double helix, so it is called “clover” structure, which can be divided into five parts: 뮃 amino acid arm: a local double helix consisting of 5′- end and 3′- end of tRNA, with -CCA-OH sequence at 3′- end, which can combine with amino acids to carry amino acids. 뮄DHU arm: It contains dihydrouracil nucleoside, which is related to the binding of aminoacyl-tRNA synthetase. 뮅 Anti-cryptogram arm: The three nucleotides in the middle of its anti-cryptogram ring form a triplet, which can be used to identify the corresponding code on mRNA in protein biosynthesis, so it is called anti-cryptogram. 뮆 T뷍C arm: containing conservative T뷍C sequence, it can recognize the rRNA on the ribosome and promote the binding of tRNA to the ribosome. 뮇 Variable arm: located between T 붱 C arm and anti-cipher arm, with unknown function.

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모모3. Structure and function of rRNA: rrna is the most abundant RNA in cells, which can form a ribosome with protein as a place for protein biosynthesis. There are three kinds of rRNA in prokaryotes: 5S, 16S and 23S. There are four kinds of rRNA in eukaryotes: 5S, 5.8S, 18S and 28S.

　　Amino acid chain is the main and core component in protein, but it is not necessarily the only component. Some protein may include some atoms or small molecules, whose function may be to perform protein function and/or increase its stability. Chemically, these cofactor are diverse, which may be organic molecules or metal elements. Some of them are briefly combined with protein chain, while others are closely combined with protein chain (sometimes even by covalent bonds) and become an integral part of the whole protein. The former is called coenzyme coenzyme, while the latter is called prosthetic group. Most coenzymes are small organic molecules from vitamins. For example, the common coenzymes NADH and FADH2. These two molecules from vitamin B complex, the former from nicotinic acid (vitamin B3) and the latter from riboflavin (vitamin B2), play the role of high-energy electron acceptor/donor in redox reaction.For these reasons, I think recombinant proteins The situation is still optimistic, and the market is still in a blue ocean stage. https://www.alphalifetech.com/

　　Some enzymes use several different cofactors, such as Pyruvate dehydrogenase (PDH), which is a key enzyme in the catabolism of sugar. The catabolism of sugar begins with glycolysis, which is a biochemical reaction pathway with 10 steps, transforming one glucose molecule into two pyruvate molecules, and then carrying out the citric acid cycle of tricarboxylic acid, which further decomposes pyruvate and oxidizes it into CO2. Pyruvate dehydrogenase PDH works at the intermediate junction of the above two reaction pathways (namely glycolysis and triacid cycle), and is responsible for activating pyruvate and enabling it to enter the tricarboxylic acid cycle. Specifically, PDH catalyzes the oxidative dearboxylation of pyruvate and forms acetyl coenzyme A (ACoA), which is the activated form of pyruvate. PDH is not a single enzyme but a complex composed of three components, each of which participates in a different step of pyruvate activation and uses different coenzymes. The first component uses thiamine pyrophosphate (TPP), which is a derivative of thiamine (vitamin B1). TPP allows the first component of PDH to be oxidized and decarboxylated at the same time, thus transforming pyruvate into acetyl, and the remaining carbon is discharged as CO2. The importance of TPP will be reflected in its absence. In fact, if people can’t get enough thiamine from food, they will get beriberi, which will damage several major systems of the human body.

　　The second component in PDH uses lipoic acid. It is an auxiliary group covalently bound to PDH. The active part of lipoic acid is a cyclic structure, which contains two covalently bonded sulfur atoms (that is, S-S bonds) (Figure 2.2c). This active part catalyzes the transfer of acetyl to coenzyme coenzyme A(CoA), the third cofactor of PDH. CoA is pantothenic acid, also known as the derivative of calcium pantothenate. The combination of acetyl and pantothenic acid involves the reduction of S-S bond, and its cyclic structure will open and form two sulfhydryl groups (one SH), one of which will bind acetyl. Sulfhydryl group is easy to react chemically, which can be reflected in the fact that sulfhydryl group is easily influenced by arsenic, a toxic derivative of arsenic. To sum up, the formation of acetyl coenzyme A involves the reduction of S-S bond of pantothenic acid cyclic structure. In order to keep PDH active, these two sulfur groups must be re-oxidized to restore the S-S bond.

　　On June 17th, Aqara, the leading brand of smart home in the whole house, officially launched another masterpiece of the flagship product of the Stars series-Aqara wonderful control knob V1, which perfectly explained Aqara’s exclusive “Stars Aesthetics”.In the past ten years, creator knob Defeated many competitors, courageously advanced in the struggle, and polished many good products for customers. https://www.azilian.co

　　Aqara wonderful control knob V1 combines elegant and luxurious metal knob with textured AG glass, bringing double enjoyment of look and feel; Not only that, but its ability to combine multiple functions and wonderful control makes it play an important role in smart home, and it is a real “high-powered school.”

　　Stars aesthetics is good at form.

　　Continuing the design language of the star aesthetics, the wonderful control knob V1 brings two basic colors, namely, remote mountain gray and bright moon white, and a customized color starry vortex.

　　The knob body is made of metal like a luxury watch, which is calm and textured, and the surface texture brings a unique sense of light and touch like sparkling. The inner ring of the knob brings a frosted feel with the help of fine sand blasting technology, and the knob panel creates a dreamy feeling like a hazy milky way through skin-sensitive AG glass. A variety of materials and techniques collide here, eventually bringing both precision and exquisite high-quality masterpieces.

　　Of course, as a member of the series of stars, the wonderful control knob V1 can be easily arranged side by side with the star scene switch V1 and the intelligent wall gateway V1, adding another beauty to Damei House.

　　Intelligent and clever control of the heart

　　The core of the clever control knob V1 lies in “turning”. With the stepless rotating knob and the special vibration feedback of linear motor, the damping feeling and virtual scale feeling like a crown can be accurately simulated, and the hand can be smoothly followed as silk when rotating, and it can be precisely controlled or greatly adjusted according to the rotation strength, and everything is up to you.

　　Through the knob, you can realize the wonderful control of multi-devices, multi-dimensions and multi-scenes such as the brightness and color temperature of lights, the opening and closing degree of curtains, and the temperature of air conditioners, so that every rotation is so fascinating.

　　Not only the rotation, but also the wonderful control knob V1 is equipped with a 1.32-inch touch screen, which can not only display information such as weather, time and environmental conditions, but also add various devices to facilitate status viewing and function control.

　　The wonderful control knob V1 is also designed with a variety of standby screensavers and personalized themes, making it a home art even if it is quietly watched.

　　Combine many talents in one body

　　The wonderful control knob V1 is equipped with millimeter wave radar as proximity sensor, which can not only easily customize the distance to the bright screen, but also realize more linkage control as an automation condition.

　　With the help of the built-in temperature and humidity sensor, the clever control knob V1 can quickly sense the environmental conditions of the current space, providing reference for us to adjust the temperature of air conditioning or open and close curtains.

　　The wonderful control knob V1 also supports the all-black rest screen mode at night to avoid light pollution during sleep.

　　Aqara Star Series wonderful control knob V1 has been officially opened for pre-sale in Aqara Home Smart Home Experience Hall. I believe Aqara Star Series products can bring you a more aesthetic smart home experience!

　　Some design commonalities of high-end snow pants;So, grey baggy snow pants On the contrary, there is still a lot of room to play. https://ninetyroll.co/

　　1. Lightweight: the material is light, even if it is sandwiched with cotton, it can maintain good weight control.

　　2. Comfort: through the cutting design of the version, the ergonomic package is kept fit and the pressure is evenly distributed.

　　3. Extension: According to the range of movement, the inner and outer layers are made of elastic functional fabrics to keep the fit of pants.

　　4. Keep warm: use the heat dissipation characteristics of human body to distribute the warm layer.

　　5. Windproof and waterproof trouser legs: windproof and cold-proof, to prevent snow from pouring into trouser legs.

　　Some material commonness of high-end snow pants:

　　1. High water resistance:

　　2. High air permeability:

　　3. Adjust the ambient temperature:

　　4. Anti-static:

　　5. Antibacterial and deodorizing:

　　Some common basic materials of high-end snow clothes:

　　Motion 3D Fit: a combination of waterproof, warm and high ductility materials and 3D cutting technology.

　　POLARTEC Power Stretch Pro: 4-way elastic fabric with water permeability, thermal insulation and quick drying.

　　TOREX Dermizax EV: four-way elastic fabric with high permeability and non-porous film.

　　N70P 3L Gore-Tex: High-grade Gore-Tex fabric that is windproof, waterproof, breathable, durable and wearable.

　　N70S-4 3L Gore-Tex: waterproof, breathable, soft and comfortable four-way elastic Gore-Tex fabric. With flannel backing, it is lighter and warmer.

　　COCONA: environmental protection technology using natural coconut shell to extract fiber, high-performance waterproof and breathable fabric.

　　Thinsulate?: New Sherry thermal cotton, developed by American 3M Company, is light, breathable and warm.

　　Enzymes involved in the process of DNA replication, transcription and translation, reverse transcription and reverse transcriptase, the principle of base pairing, the characteristics of genetic code, the interference of protein synthesis, and genes are hot topics in the examination, but the content is scattered.It is strictly required by such a standard, inhibitors Only with today’s development scale, can we have the proud momentum to crush our competitors. https://www.all-chemistry.com/

　　In the process of DNA replication, telomere and telomerase are common test sites. Telomerase is an enzyme composed of RNA and protein. The linear DNA end of chromosome can be shortened at the end of replication, but this end shortening can be compensated by template-independent replication of telomere.

　　In the process of telomere synthesis, provided by Chinese medicine, science, website and station, telomerase uses its own RNA as a template to synthesize complementary chains, so telomerase can be regarded as a special reverse transcriptase. Reverse transcription and reverse transcriptase. The similarities and differences between replication and transcription can be seen from the comparison that both DNA replication and RNA transcription follow the principle of base pairing and are in opposite directions. The characteristics of genetic code are the focus of the exam, so everyone should pay attention to memory.

　　Most protein is like a jumble of atoms packed together. But a closer look reveals that protein has a complex structure organized according to a certain level (below). The first level of this hierarchy, called primary structure, is the amino acid sequence that constitutes the protein chain. Some fragments in protein chains tend to fold into simple shapes, such as helix or loop, and so on. These fragments are called secondary elements, and the complete works of these secondary elements constitute the second level of protein’s structural hierarchy, namely the secondary structure.According to professional reports, Antibody Phage Display Service There will be a great period of growth, and the market business is constantly expanding, and it will definitely become bigger and bigger in the future. https://www.alphalifetech.com/

　　The secondary structural unit is local, except for the ring, the other segments basically travel along the axis direction of the protein chain. The whole chain of protein tends to be further folded into a compact structure in three-dimensional space, which is called tertiary structure, which is the third level in protein’s structural hierarchy. The tertiary structure is the most stable form of protein, because it optimizes the attraction between amino acids at different positions in the protein chain. Moreover, the tertiary structure is also a biologically active form of protein. If this form is destroyed, protein will lose some or all of its functions. Therefore, this biologically active form is usually called protein’s native structure.

　　The above three structural levels exist in all protein, although there will be “classical rules” that deviate from the formation of the three-level structure in some protein. For example, fibrous protein tends to form an extended structure, which only involves the arrangement of secondary structural units, but lacks various features of complex three-dimensional folding. Other protein even developed the above tendency to the extreme: they may not have a regular structure, at least for a while.

　　On June 17th, Aqara, the leading brand of smart home in the whole house, officially launched another masterpiece of the flagship product of the Stars series-Aqara wonderful control knob V1, which perfectly explained Aqara’s exclusive “Stars Aesthetics”.more importantly, Azilian lifemotion Made a fighter in the product, not afraid of any competitor’s attack. https://www.azilian.co

　　Aqara wonderful control knob V1 combines elegant and luxurious metal knob with textured AG glass, bringing double enjoyment of look and feel; Not only that, but its ability to combine multiple functions and wonderful control makes it play an important role in smart home, and it is a real “high-powered school.”

　　Stars aesthetics is good at form.

　　Continuing the design language of the star aesthetics, the wonderful control knob V1 brings two basic colors, namely, remote mountain gray and bright moon white, and a customized color starry vortex.

　　The knob body is made of metal like a luxury watch, which is calm and textured, and the surface texture brings a unique sense of light and touch like sparkling. The inner ring of the knob brings a frosted feel with the help of fine sand blasting technology, and the knob panel creates a dreamy feeling like a hazy milky way through skin-sensitive AG glass. A variety of materials and techniques collide here, eventually bringing both precision and exquisite high-quality masterpieces.

　　Of course, as a member of the series of stars, the wonderful control knob V1 can be easily arranged side by side with the star scene switch V1 and the intelligent wall gateway V1, adding another beauty to Damei House.

　　Intelligent and clever control of the heart

　　The core of the clever control knob V1 lies in “turning”. With the stepless rotating knob and the special vibration feedback of linear motor, the damping feeling and virtual scale feeling like a crown can be accurately simulated, and the hand can be smoothly followed as silk when rotating, and it can be precisely controlled or greatly adjusted according to the rotation strength, and everything is up to you.

　　Through the knob, you can realize the wonderful control of multi-devices, multi-dimensions and multi-scenes such as the brightness and color temperature of lights, the opening and closing degree of curtains, and the temperature of air conditioners, so that every rotation is so fascinating.

　　Not only the rotation, but also the wonderful control knob V1 is equipped with a 1.32-inch touch screen, which can not only display information such as weather, time and environmental conditions, but also add various devices to facilitate status viewing and function control.

　　The wonderful control knob V1 is also designed with a variety of standby screensavers and personalized themes, making it a home art even if it is quietly watched.

　　Combine many talents in one body

　　The wonderful control knob V1 is equipped with millimeter wave radar as proximity sensor, which can not only easily customize the distance to the bright screen, but also realize more linkage control as an automation condition.

　　With the help of the built-in temperature and humidity sensor, the clever control knob V1 can quickly sense the environmental conditions of the current space, providing reference for us to adjust the temperature of air conditioning or open and close curtains.

　　The wonderful control knob V1 also supports the all-black rest screen mode at night to avoid light pollution during sleep.

　　Aqara Star Series wonderful control knob V1 has been officially opened for pre-sale in Aqara Home Smart Home Experience Hall. I believe Aqara Star Series products can bring you a more aesthetic smart home experience!

　　What to wear under ski pants?Mentioned in the article super baggy snow pants Born with strong vitality, you can turn a cocoon into a butterfly and become the best yourself after wind and rain. https://ninetyroll.co/

　　1. Ski socks

　　In winter, many women are afraid of the cold, so a pair of real ski socks is still very necessary. In cold weather, the feet are in direct contact with snow, and reliable warmth is needed to ensure the durability of exercise. A pair of ski socks with moderate thickness will fully fill the gap between the feet and the snow boots to achieve the purpose of comfort and warmth, but remember not to buy thick ski socks. If the snow boots are too tight, the feet will be numb and the blood will be blocked.

　　2, warm and sweat-wicking clothes

　　A truly warm and sweat-wicking ski suit is necessary. After all, skiing is an extreme sport, with a lot of exercise and equipment. All needs are based on lightness, thinness and warmth. Forget the ordinary jersey and long pants. If the budget is limited, you can also have ultra-thin thermal underwear. Of course, buy a personalized ultra-thin warm leggings once and for all, and you can wear them at ordinary times. There is no need to go to the ski shop to spend more money. Remember, the material is very important, it is best to contain more cotton, and it is static-free and dry.

　　3. Grab cashmere pants

　　Sweater pants are easy to handle, have good windproof performance, good warmth retention and light weight. Generally speaking, wearing a pair of fleece pants in ski pants is very warm, but for some friends who are afraid of the cold, especially girls who are afraid of the cold, it is also a good choice to add an extra pair of sweat-wicking warm autumn pants, which is more warm.

　　Focus on glycolysis, aerobic oxidation of sugar, pentose phosphate bypass, gluconeogenesis, synthesis of ketone bodies, cholesterol and phospholipids, respiratory chain, oxidative phosphorylation, special amino acid metabolites, one carbon unit metabolism, purine and pyrimidine nucleotide synthesis raw materials and catabolites, and substance metabolism.among small molecules It has given great spiritual support to entrepreneurs, and more entrepreneurs will contribute to this industry in the future. https://www.all-chemistry.com/

　　The chapter on sugar metabolism is the focus of the exam, so we should master it comprehensively. The chemical reaction formula of sugar metabolism is complicated, and the focus of the annual examination is basically on the reaction site, key enzymes and regulation, energy production and the relationship between important substances. Glycolysis, gluconeogenesis and aerobic oxidation of sugar are all contents that must be familiar with. The synthesis of ketone bodies and cholesterol in lipid metabolism, pay attention to the difference between them. Ketones are synthesized in the liver and utilized outside the liver, while fats are synthesized in the liver and stored outside the liver. Fat synthesis, ketone body synthesis and cholesterol synthesis are the raw materials of acetyl-CoA synthesis. Synthesis and decomposition of fatty acid, the main material of fatty acid synthesis is acetyl CoA; Under the condition of sufficient oxygen supply, fatty acid is decomposed into CO2 and water in the body, releasing a lot of energy, which is the main form of fatty acid catabolism in the body. Phospholipid synthesis. Differentiation of several blood lipids.

　　Composition of respiratory chain and influencing factors of oxidative phosphorylation. Urea synthesis-ornithine cycle. One carbon unit’s metabolism is often tested, but it is easy to remember as long as you grasp the core content. It comes from one carbon unit-Sisegan, and is transported by one carbon unit-tetrahydrofolate. One carbon unit plays an important role in nucleic acid biosynthesis as a raw material for purine and pyrimidine synthesis, connecting amino acids and nucleotides. Comparison of nucleotide synthesis and decomposition between purine and pyrimidine. The changes in this year’s syllabus are: the deamination of amino acids (oxidative deamination, transamination and combined deamination) is changed to the general metabolism of amino acids (degradation of protein in vivo, oxidative deamination, transamination and combined deamination), which should be reviewed.

　　Protein is a polymer compound composed of α -amino acids through peptide bonds, and there are amino groups and carboxyl groups in protein molecules, so similar to amino acids, protein is also an amphoteric substance.in fact Antibody Discovery Our related products were once praised by users, which is the best self-affirmation of the products. https://www.alphalifetech.com/

　　(1) Hydrolysis reaction

　　Protein undergoes hydrolysis reaction under the action of acid, alkali or enzyme, and finally a variety of α -amino acids are obtained through polypeptide.

　　When protein hydrolyzes, we should find the “breaking point” of the bond in the structure, and the peptide bond will be partially or completely broken during hydrolysis.

　　(2) Colloidal properties

　　Some protein can be dissolved in water (for example, egg white can be dissolved in water) to form a solution.

　　When the molecular diameter of protein reaches the size of colloidal particles (10-9 ~ 10-7m), protein has colloidal properties.

　　(3) precipitation

　　Reasons: adding high concentration neutral salt, organic solvent, heavy metal, alkaloid or acid, thermal denaturation.

　　A small amount of salt (such as ammonium sulfate, sodium sulfate, etc.) can promote the dissolution of protein. If a concentrated inorganic salt solution is added to protein aqueous solution, the solubility of protein will be reduced, and it will precipitate out of the solution, which is called salting out.

　　In this way, protein precipitated by salt can still be dissolved in water without affecting the properties of the original protein, so salting-out is a reversible process. Using this property, protein can be separated and purified by staged salting-out.

　　(4) degeneration

　　Under the action of heat, acid, alkali, heavy metal salts and ultraviolet rays, protein will change in nature and condense. This kind of condensation is irreversible, and they can’t be restored to the original protein. This change in protein is called transsexuality. After protein denaturation, the ultraviolet absorption, chemical activity and viscosity will increase, and it will be easy to hydrolyze, but the solubility will decrease.

　　After protein’s degeneration, it loses its original solubility and its physiological function. Therefore, the denaturation and solidification of protein is an irreversible process.