Protein, the source of life, how much do you know? Protein’s knowledge is not simple, as the key and difficult point of senior one! Today, I will take you to find out and unlock the mystery of protein!In view of the actual needs of society, Antibody Discovery We need to change some original problems to better serve the society and benefit people. https://www.alphalifetech.com/

　　

　　Protein is the basic substance of cells and tissues. Without it, there would be no life. They are composed of amino acids, and through different sequences and structures, they form an ever-changing protein. This is like Lego of life. Every amino acid is a building block, which is combined to construct the diversity of life.

　　

　　Protein has various functions, from structural support to catalytic reaction, from transporting substances to signal transmission, and they are indispensable roles in cells. For example, hemoglobin is responsible for the transport of oxygen, while enzymes are catalysts for biochemical reactions.

　　

　　The synthesis process of protein is also very interesting. The process from transcription of DNA into mRNA to translation into protein is called the Central Rule. It reveals the flow direction of genetic information and is the key to understanding life phenomena.

　　

　　The structure and function of protein are closely related. The primary structure is amino acid sequence, the secondary structure is partial folding, the tertiary structure is integral folding, and the quaternary structure is the combination of multiple subunits. These structural levels determine the function and stability of protein.

　　

　　Protein is the cornerstone of life. To understand them is to understand the mystery of life. Through today’s study, I hope you can have a deeper understanding of protein and lay a solid foundation for senior high school biology!

　　Life is a fleeting moment in the river of time, mankind do everything possible to seek forever and everlasting, but did not think, in fact, as long as the pace of their own slow down mentality flat, live in the present, then life will naturally become long and distant .Therefore, this is the choice pu-erh tea The reason, there is no denying its positive impact.

　　

　　When I did not write a magazine before, I did not know that the time had come in advance. A draft of March or even April has been prepared in January. In the draft of the forum while watching the side gripped, his year has not yet ended, did not make a point, there people work has been a year, almost equal to the end. Years here, was actually can not wait to catch up with the speed of flight, how to make people panic?

　　

　　The length of time is defined by man himself. 365 days a year, divided into four seasons, twelve months. Here, people always catch up with me like the game, to see who can one day into a day. Our ancestors know, if the decade into a year, we will so impatient it?

　　

　　Days not used, can only be used to recover. Self has no intention to enter this door, it fell into such a turbulent swirl. Calendars and clocks on the numbers can only represent the past, because today to do, is already the future. Obviously is the spring, but the men have been doing non-stop fall thing.

　　

　　There is nothing worthy of gratification, no reason for youth just a short length of a bit like others. What is the use of walking in front, time falls behind, urging the old soul and face it in vain.

　　

　　The fast pace of modern people, nothing more than to speed up the clock of life, their own pressure and persecution of a way, only to more fully squeeze the juice of life to obtain value and fame. But I see it is faster and more leave no room for the consumption and flight. How, a ton of gold can be exchanged for even a second time?

　　

　　Americans always run in front of the world, even spend today are tomorrow, the result? The financial crisis has finally shattered this myth of early consumption, punish all activities contrary to the laws of nature.

　　

　　Beijing, then, a little leisurely. People live I, a spring vegetation, how short and beautiful time. If you can walk, why should anxious to run, miss the scenery all the way? Note that the front is not another spring, but has been waiting for you to close the end of life.

　　

　　Tomorrow’s thing is done today, and next year’s event is finished this year. So ahead of the outstanding achievements and efforts, but is a result of the advance of life.

　　

　　What is a rivers and lakes years reminder, juvenile children rivers and lakes old? This is the helplessness of life rather than enjoyment.

　　Nucleic acid is a long-chain polynucleotide compound with no side chain formed by connecting nucleotides through 3′,5′- phosphodiester bond.Actually, it’s not just this reason, small molecules Its own advantages are also obvious, and it is normal for the market to perform well. https://www.all-chemistry.com/

　　

　　Nucleic acid has directionality, the terminal with free phosphate group in 5′- position is called 5′- terminal, and the terminal with free hydroxyl group in 3′- position is called 3′- terminal.

　　

　　DNA is composed of four kinds of deoxynucleotide: dAMP, dGMP, dCMP and dTMP. Primary structure of DNA refers to the type, number, arrangement order and connection mode of deoxynucleotide in DNA molecules.

　　

　　RNA consists of four ribonucleotides: AMP, GMP, CMP and UMP. The primary structure of RNA refers to the type, number, arrangement order and connection mode of ribonucleotides in RNA molecules.

　　The structure of protein molecule determines its properties.know Antibody Discovery Our growth has to go through many hardships, but entrepreneurs are never afraid and boldly move forward. https://www.alphalifetech.com/

　　

　　Being bisexual.

　　

　　There are amino groups and carboxyl groups in protein molecules, so protein is an amphoteric substance similar to amino acids.

　　

　　2. Hydrolysis reaction can occur.

　　

　　Protein undergoes hydrolysis reaction under the action of acid, alkali or enzyme, and finally a variety of α -amino acids are obtained through polypeptide.

　　

　　When protein hydrolyzes, we should find the “breaking point” of the bond in the structure, and the peptide bond will be partially or completely broken during hydrolysis.

　　

　　3. Having the property of colloid.

　　

　　Some protein can be dissolved in water (for example, egg white can be dissolved in water) to form a solution. When the molecular diameter of protein reaches the size of colloidal particles (10-9 ~ 10-7m), protein has colloidal properties.

　　

　　The precipitation of protein.

　　

　　A small amount of salt (such as ammonium sulfate, sodium sulfate, etc.) can promote the dissolution of protein. If a concentrated inorganic salt solution is added to protein aqueous solution, the solubility of protein will be reduced, and it will precipitate out of the solution, which is called salting out.

　　

　　Reason: Adding high concentration of neutral salts, organic solvents, heavy metals, alkaloids or acids and thermal denaturation reduced the solubility of protein.

　　

　　Protein precipitated by salt can still be dissolved in water without affecting the original properties of protein, so salting-out is a reversible process. Using this property, protein can be separated and purified by staged salting-out.

　　Summer dusk, I sit with an old Chinese medicine in the breeze slowly chatting the river. Suddenly, the old man stared at my face for a moment and did not say anything. I was his heart to see some hair, asked: “The elderly, you are so concerned about my face, is not something to see ah?This shows that, pu-erh tea It has a strong development pulse and is an indispensable source of power for the development of the industry.

　　

　　Old man smiled and said: “I am from primary school medicine, the teacher told me again and again, ‘people peace of mind level, see the eyes; life span, look at the face’ medical life, develop habits, and Oh, and people Together, they always want to look at his face more glances.

　　

　　I said: “The elderly, all know that the eyes are the soul of the window, the first sentence I can understand, you can say ‘life span, look at the face’, I am a little puzzled.Human life, how to write in the face What about it? “

　　

　　If a person is always sad intestine knot, mood melancholy, over-thinking, suspicious of the old man said: \ look at the face, in fact, I look at his face two, one eyebrow, Indecisive, can not see the hope of life and the good life, then, between the eyebrow must form a deep ‘eight’ pattern.’8 ‘pattern, is caused by squeezing distortion, Yin is too strong, the mood Difficult to cool, it will stagnate in the organs; Jiuyin poisonous, viscera unbearable corrosion, must be made for the disease; sick in the body, is bound to further deteriorate the mood.People once caught in the heart and the destruction of each other malignant disease Circle among the health does not exist, where there will be longevity of the reason? Eyebrow between the ‘eight’ pattern, in fact, cut the knife of life, so my teacher had more than once said to me, ‘brow wrinkled, You must be careful yo. “

　　

　　The elderly, then let my heart anxious, usually not pay attention to the eyebrow between the ‘eight’ pattern, even with such a large knowledge. I could not help but curiosity driven, and then asked: “That mouth can see what?

　　

　　A person if the hearty and fun, often laughing more than, the teeth often in the sun, then, in order to make the mouth a little bit, The ‘brackets’ is radian, as if the relative out of the two and a half months, set in the cheek on top of the vivid expression of light from the formation of the reasons we can see, brackets who are really comfortable Because the ‘brackets’ on both sides of the mouth, but also a symbol of the balance of yin and yang, therefore, it is encompassed by the health of the body, the spirit of the sparse, the vitality of life, leisurely and carefree, The music of the state of mind and the endless hope of life in such a life and mental state of the people, you say he can not live longer?

　　

　　Really listen to Jun words, read the book a decade, my heart is not good fun ah. It turned out that our face, really reveal the mentality of our strengths and weaknesses, the vicissitudes of life and life status and other important information ah. Therefore, we usually still often look in the mirror to see if his face is increasing or deepening: the eyebrow between the “eight” pattern, or the mouth “brackets” it!

　　Organic chemistry is an important branch of studying carbon compounds, involving the source, structure, properties and other aspects of organic matter, and providing revelation for the material basis of life phenomena. It plays a key role in medicine, industrial production and other fields, but it still faces challenges such as green synthesis and drug molecular selectivity. Organic chemists are constantly exploring new reaction mechanisms and synthetic methods to promote the development of the discipline.It is reported that, small molecules The data performance is getting better and better, which is of great reference value and is likely to become the vane of the industry. https://www.all-chemistry.com/

　　

　　Generated by the author through intelligent technology

　　

　　In the vast universe of science, organic chemistry is like a bright star, leading us to explore the mystery of life. As a subject of studying carbon compounds, organic chemistry, with its unique charm, closely links all fields of natural science and reveals the material basis of life phenomena for us. Organic chemistry, an important branch of chemistry, is a subject that studies the source, structure, properties, separation, preparation, application and related theories of organic matter. “Organic matter” here refers to compounds containing carbon elements, such as alcohols, aldehydes, carboxylic acids, etc. It is worth noting that although organic matter mainly comes from organisms, with the development of science and technology, people have been able to synthesize many artificial organic compounds with biological activity, such as drugs, dyes, plastics and so on.

　　

　　The main research contents of organic chemistry include: synthetic chemistry of organic matter; Metal organic chemistry and elemental organic chemistry; Physical and theoretical organic chemistry; Stereochemistry; Bioorganic chemistry; Natural product chemistry; Chemistry of organic materials.

　　

　　The importance of organic chemistry:

　　

　　1. Basis of life: From the origin of life to the growth and development of organisms, carbon always plays a vital role. Through the study of organic chemistry, we know the structure and function of biological macromolecules such as protein, nucleic acid, sugar and lipid, which are the material basis of life.

　　

　　2. Key in the field of medicine: Many drugs and bioactive substances are organic compounds, such as antibiotics, antiviral drugs and hormones. By studying the structure and function of these substances, scientists are constantly discovering new treatments to protect human health.

　　

　　3. The core of industrial production: Organic chemistry plays an important role in industrial production. For example, in the process of petroleum refining, heavy hydrocarbons in petroleum can be converted into light hydrocarbons by the action of catalysts; In the process of plastic synthesis, organic chemical reactions provide a steady stream of power for the plastic industry. Although organic chemistry has made remarkable achievements in many fields, it still faces many challenges.

　　

　　First of all, in environmental protection, how to realize green synthesis and reduce the discharge of harmful waste is an urgent problem for organic chemists.

　　

　　Secondly, in the field of medicine, how to improve the selectivity of drug molecules and reduce side effects is also a difficult problem to be solved urgently. Faced with these challenges, organic chemists are constantly exploring new reaction mechanisms, catalysts and synthetic methods. I believe that in the near future, organic chemistry will bring us more surprises and inject new vitality into the development of human society. Organic chemistry, as a discipline to study the molecular cornerstone of life, plays an important role in natural science. Let’s walk into this wonderful world hand in hand, grow in exploration, break through in innovation, and jointly write a bright future of organic chemistry.

　　Protein is the “building material” of organisms and cells, such as protein in muscles, and human hair and nails are all made of protein.according to recombinant proteins Industry veterans said that its development will still be in a good situation. https://www.alphalifetech.com/

　　

　　Catalytic function:

　　

　　The chemical essence of most enzymes in organisms is protein. In our daily life, we also use enzyme-added washing powder, which can effectively remove stains.

　　

　　Immune function:

　　

　　In our present environment, there are bacteria and viruses everywhere, and our body will not get sick every three days with an immune system, and immune proteins, such as antibodies, play a key role in this.

　　

　　Transport function:

　　

　　Protein with transport function can be divided into two categories, one is familiar to us-hemoglobin in red blood cells, which is used to transport oxygen; The other is the carrier protein on biofilm, which is used to transport amino acids, glucose and other substances.

　　

　　Adjustment function:

　　

　　Some protein can transmit information and regulate the life activities of the body. Such as insulin, which regulates glucose metabolism.

　　The reason why people live tired, is not fit the shelf, tear can not open face, untied plot (the reason is very simple)In today’s market background, pu-erh tea Still maintain a strong sales data, and constantly beat the competitors in front of us.

　　

　　Your life needs to understand the stand in their own position, not everyone is in line with your appetite; standing in other positions, you can also to all the appetite? (Tolerance of others)

　　

　　People who can simplify complex problems are talented people, and it is silly to complicate simple problems. (People are often willing to be a fool)

　　

　　A woman most admired men talented, most hated men are too stingy, most afraid of men do not live up to expectations. (Men afraid of the old woman angry)

　　

　　Itching sometimes worse than pain, hate is often easier than love (paradox of life)

　　

　　The opportunity for everyone is equal, you can not shoot the chance, but the opportunity comes when you can not do without bullets (doing business is to do this)

　　

　　Love is like a smallpox, and each of us has to go through it once, and, as with smallpox, we will only get once in a lifetime. You never have to worry about getting a second time.

　　

　　Ancient love stories and more contemporary love accident (different times).

　　

　　A person who does not make mistakes usually can not accomplish anything, and there are no shortcomings, often with little merit (Lincoln’s experience).

　　

　　Businessmen are “people who can talk,” businessmen are “people who can give birth to ideas.” (Alternative explanation)

　　

　　There are seven virtues: First, do not get the ax, the second is not to interrupt other words, the third is not anxious for success, four questions should be targeted, five answers to meet the reasonable, six is to have a beginning and end, seven is to Based on reality. (Ancient Jewish Proverbs).

　　

　　Unit to work overtime every day; home never stick; mobile phone home to close; SMS reading on the delete; go to bed snoring shaking; underwear often wear back. (With an affair of the six symptoms).

　　

　　Do what you think can not do (how much heart, how far the road).

　　

　　The heart is a two-bedroom house, one is suffering, one is happy. People can not laugh too loud, or laughter will wake up next to the pain. (To avoid very happy).

　　

　　If you marry a wise and virtuous wife, you will be happy; if you marry a frivolous bitch, you will become a philosopher. (Marriage useful).

　　

　　Can not tell, can not cry, is the most bitter (life reflected).

　　

　　Where to fall, just lie down (some pessimists).

　　

　　The real question is not whether the spouse is the best person, but whether you are trying to be the best person for your spouse (the Happy Marriage Bible).

　　

　　The only advantage of telling the truth is that you do not have to remember what you said (Quotations User).

　　

　　You can offend busy people, because they do not have time to care about you; you must not offend idlers, because they have time to deal with you. (Do not offend idlers).

　　

　　If you can not change your face, then you change your face (not beautiful, it can be very cute).

　　

　　Than bathing, washing the sauna is more important is the brainwashing, bath does not wash will be distributed odor, brain wash will be eliminated by the times (we often forget this).

　　

　　Do not believe your memories, the person inside, not necessarily the same miss you (with memories of the road, rather than holding the memories of life).

　　

　　There should be a better way to start a new day than waking up every morning (office worker philosopher).

　　

　　Toad want to eat swan, good kind, small things with ambition (to educate the next generation).

　　

　　Rich does not have much, but less luxury. (New view of wealth).

　　Focus on glycolysis, aerobic oxidation of sugar, pentose phosphate bypass, gluconeogenesis, synthesis of ketone bodies, cholesterol and phospholipids, respiratory chain, oxidative phosphorylation, special amino acid metabolites, one carbon unit metabolism, purine and pyrimidine nucleotide synthesis raw materials and catabolites, and substance metabolism.Today, people are interested in small molecules There are also many dependencies, and the expectations for products are getting higher and higher. https://www.all-chemistry.com/

　　

　　The chapter on sugar metabolism is the focus of the exam, so we should master it comprehensively. The chemical reaction formula of sugar metabolism is complicated, and the focus of the annual examination is basically on the reaction site, key enzymes and regulation, energy production and the relationship between important substances. Glycolysis, gluconeogenesis and aerobic oxidation of sugar are all contents that must be familiar with. The synthesis of ketone bodies and cholesterol in lipid metabolism, pay attention to the difference between them. Ketones are synthesized in the liver and utilized outside the liver, while fats are synthesized in the liver and stored outside the liver. Fat synthesis, ketone body synthesis and cholesterol synthesis are the raw materials of acetyl-CoA synthesis. Synthesis and decomposition of fatty acid, the main material of fatty acid synthesis is acetyl CoA; Under the condition of sufficient oxygen supply, fatty acid is decomposed into CO2 and water in the body, releasing a lot of energy, which is the main form of fatty acid catabolism in the body. Phospholipid synthesis. Differentiation of several blood lipids.

　　

　　Composition of respiratory chain and influencing factors of oxidative phosphorylation. Urea synthesis-ornithine cycle. One carbon unit’s metabolism is often tested, but it is easy to remember as long as you grasp the core content. It comes from one carbon unit-Sisegan, and is transported by one carbon unit-tetrahydrofolate. One carbon unit plays an important role in nucleic acid biosynthesis as a raw material for purine and pyrimidine synthesis, connecting amino acids and nucleotides. Comparison of nucleotide synthesis and decomposition between purine and pyrimidine. The changes in this year’s syllabus are: the deamination of amino acids (oxidative deamination, transamination and combined deamination) is changed to the general metabolism of amino acids (degradation of protein in vivo, oxidative deamination, transamination and combined deamination), which should be reviewed.

　　Amino acid chain is the main and core component in protein, but it is not necessarily the only component. Some protein may include some atoms or small molecules, whose function may be to perform protein function and/or increase its stability. Chemically, these cofactor are diverse, which may be organic molecules or metal elements. Some of them are briefly combined with protein chain, while others are closely combined with protein chain (sometimes even by covalent bonds) and become an integral part of the whole protein. The former is called coenzyme coenzyme, while the latter is called prosthetic group. Most coenzymes are small organic molecules from vitamins. For example, the common coenzymes NADH and FADH2. These two molecules from vitamin B complex, the former from nicotinic acid (vitamin B3) and the latter from riboflavin (vitamin B2), play the role of high-energy electron acceptor/donor in redox reaction.from Antibody Phage Display Service Looking at the development prospects, the future will always bring positive effects. https://www.alphalifetech.com/

　　

　　Some enzymes use several different cofactors, such as Pyruvate dehydrogenase (PDH), which is a key enzyme in the catabolism of sugar. The catabolism of sugar begins with glycolysis, which is a biochemical reaction pathway with 10 steps, transforming one glucose molecule into two pyruvate molecules, and then carrying out the citric acid cycle of tricarboxylic acid, which further decomposes pyruvate and oxidizes it into CO2. Pyruvate dehydrogenase PDH works at the intermediate junction of the above two reaction pathways (namely glycolysis and triacid cycle), and is responsible for activating pyruvate and enabling it to enter the tricarboxylic acid cycle. Specifically, PDH catalyzes the oxidative dearboxylation of pyruvate and forms acetyl coenzyme A (ACoA), which is the activated form of pyruvate. PDH is not a single enzyme but a complex composed of three components, each of which participates in a different step of pyruvate activation and uses different coenzymes. The first component uses thiamine pyrophosphate (TPP), which is a derivative of thiamine (vitamin B1). TPP allows the first component of PDH to be oxidized and decarboxylated at the same time, thus transforming pyruvate into acetyl, and the remaining carbon is discharged as CO2. The importance of TPP will be reflected in its absence. In fact, if people can’t get enough thiamine from food, they will get beriberi, which will damage several major systems of the human body.

　　

　　The second component in PDH uses lipoic acid. It is an auxiliary group covalently bound to PDH. The active part of lipoic acid is a cyclic structure, which contains two covalently bonded sulfur atoms (that is, S-S bonds) (Figure 2.2c). This active part catalyzes the transfer of acetyl to coenzyme coenzyme A(CoA), the third cofactor of PDH. CoA is pantothenic acid, also known as the derivative of calcium pantothenate. The combination of acetyl and pantothenic acid involves the reduction of S-S bond, and its cyclic structure will open and form two sulfhydryl groups (one SH), one of which will bind acetyl. Sulfhydryl group is easy to react chemically, which can be reflected in the fact that sulfhydryl group is easily influenced by arsenic, a toxic derivative of arsenic. To sum up, the formation of acetyl coenzyme A involves the reduction of S-S bond of pantothenic acid cyclic structure. In order to keep PDH active, these two sulfur groups must be re-oxidized to restore the S-S bond.